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M2-PK, as measured in feces, is a potential tumor marker for colorectal cancer.When measured in feces with a cutoff value of 4 U/ml, its sensitivity has been estimated to be 85% (with a 95% confidence interval of 65 to 96%) for colon cancer and 56% (confidence interval 41–74%) for rectal cancer. [1]
The M2-PK Test is a non-invasive screening method for the early detection of colorectal cancers and polyps which are known to be the precursors of colorectal cancer. The M2-PK Test which is used for stool analysis is available either as fully quantitative ELISA Test or as a rapid test that can be performed by any general practitioner without the need of a laboratory or any additional equipment.
Tumor M2-PK is produced in all rapidly dividing cells and is responsible for enabling cancer cells to consume glucose at an accelerated rate; on forcing the cells to switch to pyruvate kinase's alternative form by inhibiting the production of tumor M2-PK, their growth was curbed. The researchers acknowledged the fact that the exact chemistry of ...
Interestingly, many of the pyruvate kinase bypassing pathways use metabolites that transit through mitochondria, highlighting the importance of mitochondria in cancer metabolism irrespective of oxidative phosphorylation. In tumor cells, PKM2 is mainly in the dimeric form and has, therefore, been termed Tumor M2-PK. The quantification of Tumor ...
lymphoma, leukemia, lung cancer, prostate cancer [17] thyroglobulin (Tg) post-operative marker of thyroid cancer (but not in medullary thyroid cancer) [9] thyroid transcription factor-1 (TTF-1) all types of thyroid cancer, lung cancer [9] Tumor M2-PK
Fecal occult blood testing (FOBT), as its name implies, aims to detect subtle blood loss in the gastrointestinal tract, anywhere from the mouth to the colon.Positive tests ("positive stool") may result from either upper gastrointestinal bleeding or lower gastrointestinal bleeding and warrant further investigation for peptic ulcers or a malignancy (such as colorectal cancer or gastric cancer).
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