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Specifically, cell differentiation in animals is highly dependent on biomolecular condensates of regulatory proteins and enhancer DNA sequences. Cellular differentiation is often controlled by cell signaling. Many of the signal molecules that convey information from cell to cell during the control of cellular differentiation are called growth ...
Directed differentiation is a bioengineering methodology at the interface of stem cell biology, developmental biology and tissue engineering. [1] It is essentially harnessing the potential of stem cells by constraining their differentiation in vitro toward a specific cell type or tissue of interest. [ 2 ]
In general, this means that a cell determined to differentiate into a brain cell cannot be transformed into a skin cell. Determination is followed by differentiation, the actual changes in biochemistry, structure, and function that result in specific cell types. Differentiation often involves a change in appearance as well as function. [18]
Anaplasia (from Ancient Greek ἀνά (ana) 'backward' and πλάσις (plasis) 'formation') is a condition of cells with poor cellular differentiation, losing the morphological characteristics of mature cells and their orientation with respect to each other and to endothelial cells.
Programmed cell death (PCD; sometimes referred to as cellular suicide [1]) is the death of a cell as a result of events inside of a cell, such as apoptosis or autophagy. [ 2 ] [ 3 ] PCD is carried out in a biological process , which usually confers advantage during an organism's lifecycle .
Transdifferentiation, also known as lineage reprogramming, [1] is the process in which one mature somatic cell is transformed into another mature somatic cell without undergoing an intermediate pluripotent state or progenitor cell type. [2] It is a type of metaplasia, which
LIF inhibits cell differentiation, and its removal allows the cell lines to go through cell differentiation. The cell lines were treated with Trichostatin A (TSA) - a histone deacetylase inhibitor for 6 days. One group of cell lines was treated with 10nM of TSA. The western analysis showed the lack of initial deacetylation on Day-1
However, cellular extensions, in general, can be found on a larger "macro" scale, occupying relatively large areas of the cell membrane. [1] For example, microglia can use their primary processes to constantly monitor and evaluate alterations in the brain environment, and they can further deploy thin filopodia from these primary processes to ...