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Like Δ 9-THC, 11-hydroxy-THC is a partial agonist at the cannabinoid receptor CB 1, but with significantly higher binding affinity (K i = 0.37 nM compared to Δ 9-THC K i = 35 nM). [7] With respect to cAMP inhibition at CB 1 it displays a similar efficacy to that of Δ 9 -THC (EC 50 = 11 nM vs. EC 50 = 5.2 nM, respectively), but a lower ...
11-Hydroxy-Δ-8-tetrahydrocannabinol (11-OH-Δ 8-THC, alternatively numbered as 7-OH-Δ 6-THC) is an active metabolite of Δ 8-THC, a psychoactive cannabinoid found in small amounts in cannabis. It is an isomer of 11-OH-Δ 9-THC, and is produced via the same metabolic pathway. It was the first cannabinoid metabolite discovered in 1970.
THC and its 11-OH-THC and THC-COOH metabolites can be detected and quantified in blood, urine, hair, oral fluid or sweat using a combination of immunoassay and chromatographic techniques as part of a drug use testing program or in a forensic investigation. [57] [58] [59] There is ongoing research to create devices capable of detecting THC in ...
A participant in a study on the effects of cannabis, shows the marijuana flowers he has grown in his backyard, in Longmont, Colorado, U.S., December 19, 2019.
These are achieved at lower doses, because many synthetic cannabinoids are more potent than marijuana, and users are often unaware of exactly what they are getting and how potent it is. [55] For example, Δ 9-THC has an EC 50 of 250 nM at CB 1 and 1157 nM at CB 2, whereas PB-22 has an EC 50 of 5.1 nM at CB 1 and 37 nM at CB 2. [8]
The short-term effects of cannabis are caused by many chemical compounds in the cannabis plant, including 113 [clarification needed] different cannabinoids, such as tetrahydrocannabinol, and 120 terpenes, [1] which allow its drug to have various psychological and physiological effects on the human body.
Since it has a longer side chain, its cannabinoid effects are "far higher than Δ 9-THC itself." Tetrahydrocannabiphorol has a reported binding affinity of 1.2 nM at CB 1, approximately 33 times that of Δ 9-THC (40 nM at CB 1). [4] THCP was studied by Roger Adams as early as 1942. [5]
Dr. Phil also expressed his belief that smoking marijuana can cause a "multi-point drop" in a person's IQ, in addition to implying that the drug's use can be associated with violent behavior.