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Staphylococcus epidermidis is a Gram-positive bacterium, and one of over 40 species belonging to the genus Staphylococcus. [1] It is part of the normal human microbiota , typically the skin microbiota , and less commonly the mucosal microbiota and also found in marine sponges.
S. epidermidis, a coagulase-negative staphylococcus species, is a commensal of the skin, but can cause severe infections in immune-suppressed patients and those with central venous catheters. S. saprophyticus , another coagulase -negative species that is part of the normal vaginal flora , is predominantly implicated in uncomplicated lower ...
SSSS is a clinical diagnosis. This is sometimes confirmed by isolation of S. aureus from blood, mucous membranes, or skin biopsy; however, these are often negative. Skin biopsy may show separation of the superficial layer of the epidermis (intraepidermal separation), differentiating SSSS from TEN, wherein the separation occurs at the dermo-epidermal junction (subepidermal separation).
Shunt nephritis is a rare condition affecting males and females of all ages. It occurs in approximately 0.7-2.3% of patients with shunt infections. Approximately 12% of ventriculoatrial shunts become infected, with Staphylococcus epidermidis being the infectious agent in 75% of cases. [1]
Infective endocarditis is an infection of the inner surface of the heart (endocardium), usually the valves. [1] Signs and symptoms may include fever, small areas of bleeding into the skin, heart murmur, feeling tired, and low red blood cell count.
Miliaria occurs when sweat glands become clogged due to dead skin cells or bacteria such as Staphylococcus epidermidis, [9] a common bacterium that occurs on the skin, which is also associated with acne. The trapped sweat leads to irritation (prickling), itching, and a rash of very small blisters, usually in a localized area of the skin.
Toxic shock syndrome (TSS) is a condition caused by bacterial toxins. [1] Symptoms may include fever, rash, skin peeling, and low blood pressure. [1] There may also be symptoms related to the specific underlying infection such as mastitis, osteomyelitis, necrotising fasciitis, or pneumonia.
Toxic shock syndrome toxin-1 (TSST-1) is a superantigen with a size of 22 kDa [1] produced by 5 to 25% of Staphylococcus aureus isolates. It causes toxic shock syndrome (TSS) by stimulating the release of large amounts of interleukin-1, interleukin-2 and tumor necrosis factor. In general, the toxin is not produced by bacteria growing in the ...