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An anal fissure is a break or tear in the skin of the anal canal. Anal fissures may be noticed by bright red anal bleeding on toilet paper and undergarments, or sometimes in the toilet. If acute they are painful after defecation , [ 1 ] but with chronic fissures, pain intensity often reduces and becomes cyclical.
Botulinum toxin, or botulinum neurotoxin (commonly called botox), is a neurotoxic protein produced by the bacterium Clostridium botulinum and related species. [24] It prevents the release of the neurotransmitter acetylcholine from axon endings at the neuromuscular junction, thus causing flaccid paralysis. [25]
Non Surgical Therapy: Constipation relief, avoid anal trauma, [8] Topical Nitrates and calcium channel blockers to relax the sphincter, [8] Botulinum Toxin injection. [9] Surgical Therapy (for chronic fissures or when non-surgical therapy fails) : Anal Dilation, [8] Lateral Internal Sphincterotomy, Advancement Flaps, Fissurectomy. Anorectal ...
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People in at least two states have been hospitalized with botulism-like illness after receiving cosmetic injections – commonly known as “botox” – that were administered in non-medical ...
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