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  2. HIV/AIDS - Wikipedia

    en.wikipedia.org/wiki/HIV/AIDS

    HIV is the cause of the spectrum of disease known as HIV/AIDS. HIV is a retrovirus that primarily infects components of the human immune system such as CD4 + T cells, macrophages and dendritic cells. It directly and indirectly destroys CD4 + T cells. [88] HIV is a member of the genus Lentivirus, [89] part of the family Retroviridae. [90]

  3. Pathophysiology of HIV/AIDS - Wikipedia

    en.wikipedia.org/wiki/Pathophysiology_of_HIV/AIDS

    These studies found that >95% of CD4 T cells die because of abortive HIV infection. [9] These dying cells are resting and thus are nonpermissive for productive HIV infection. Full viral replication was limited to the ~5% of activated CD4 T cells present in these tissues; these cells die by apoptosis. [10]

  4. HIV - Wikipedia

    en.wikipedia.org/wiki/HIV

    In cell-free spread (see figure), virus particles bud from an infected T cell, enter the blood or extracellular fluid and then infect another T cell following a chance encounter. [90] HIV can also disseminate by direct transmission from one cell to another by a process of cell-to-cell spread, for which two pathways have been described.

  5. Blood-borne disease - Wikipedia

    en.wikipedia.org/wiki/Blood-borne_disease

    A blood-borne disease is a disease that can be spread through contamination by blood and other body fluids. Blood can contain pathogens of various types, chief among which are microorganisms , like bacteria and parasites , and non-living infectious agents such as viruses .

  6. p24 capsid protein - Wikipedia

    en.wikipedia.org/wiki/P24_capsid_protein

    P24 is a structural protein that plays a crucial role in the formation and stability of the viral capsid, which protects the viral RNA. p24 capsid protein's roles in the HIV replicative process are summarized as follows: [citation needed] Fusion: HIV replication cycle begins when HIV fuses with the surface of the host cell.

  7. Sexually transmitted infection - Wikipedia

    en.wikipedia.org/wiki/Sexually_transmitted_infection

    HIV is carried in body fluids and is spread by sexual activity. It can also be spread by contact with infected blood, breastfeeding, childbirth, and from mother to child during pregnancy. [73] When HIV is at its most advanced stage, an individual is said to have AIDS (acquired immunodeficiency syndrome). [74]

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