Ad
related to: how to do reconstitution dosage calculations
Search results
Results From The WOW.Com Content Network
Before administration, a lyophilized drug is reconstituted as a liquid before being administered. This is done by combining a liquid diluent with the freeze-dried powder, mixing, then injecting. Reconstitution usually requires a reconstitution and delivery system to ensure that the drug is correctly mixed and administered.
The following formulas can be used to calculate the volumes of solute (V solute) and solvent (V solvent) to be used: [1] = = where V total is the desired total volume, and F is the desired dilution factor number (the number in the position of F if expressed as "1/F dilution factor" or "xF dilution"). However, some solutions and mixtures take up ...
Different dosage forms of iron preparation have different absorption mechanisms. Iron in oral iron preparations is absorbed in the gut via transporters and carrier proteins and released to the bloodstream. [3] Iron in parenteral iron preparation needs to be released by the cleavage of the surrounding complex by macrophages. [4]
This gives a = 100 μg/mL if the drug stays in the blood stream only, and thus its volume of distribution is the same as that is = 0.08 L/kg. If the drug distributes into all body water the volume of distribution would increase to approximately V D = {\displaystyle V_{D}=} 0.57 L/kg [ 8 ]
For a response of 0.25a.u., Drug B is more potent, as it generates this response at a lower concentration. For a response of 0.75a.u., Drug A is more potent. a.u. refers to "arbitrary units". In pharmacology , potency or biological potency [ 1 ] is a measure of a drug's biological activity expressed in terms of the dose required to produce a ...
In pharmacokinetics, a maintenance dose is the maintenance rate [mg/h] of drug administration equal to the rate of elimination at steady state. This is not to be confused with dose regimen, which is a type of drug therapy in which the dose [mg] of a drug is given at a regular dosing interval on a repetitive basis.
In clinical pharmacology, dose refers to the amount of drug administered to a person, and dosage is a fuller description that includes not only the dose (e.g., "500 mg") but also the frequency and duration of the treatment (e.g., "twice a day for one week").
In pharmacokinetics, a loading dose is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose. [ 1 ] A loading dose is most useful for drugs that are eliminated from the body relatively slowly, i.e. have a long systemic half-life .