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As a solution for the rapid metabolism of histamine, the measurement of histamine and its metabolites, particularly the 1,4-methyl-imidazolacetic acid, in a 24-hour urine sample, provides an efficient alternative to histamine measurement because the values of these metabolites remain elevated for a much longer period than the histamine itself.
The enzyme histidine decarboxylase (EC 4.1.1.22, HDC) is transcribed on chromosome 15, region q21.1-21.2, and catalyzes the decarboxylation of histidine to form histamine.In mammals, histamine is an important biogenic amine with regulatory roles in neurotransmission, gastric acid secretion and immune response.
The manifestations of histamine intolerance, or, adverse reactions to ingested histamine, are not confined to the gastrointestinal system, and are usually systemic, affecting the entire body; still, these symptoms are often sporadic and non-specific: [5] [6] [7] symptoms attributed to histamine intolerance are wide-ranging and may affect various physiological systems, including the skin ...
“Histamine is released in the body and enters the gastrointestinal tract, which can cause gas, bloating, nausea, stomach pains and diarrhea.” He notes specific foods that can make seasonal ...
Mast cell activation syndrome (MCAS) is a term referring to one of two types of mast cell activation disorder (MCAD); the other type is idiopathic MCAD. [1] MCAS is an immunological condition in which mast cells, a type of white blood cell, inappropriately and excessively release chemical mediators, such as histamine, resulting in a range of chronic symptoms, sometimes including anaphylaxis or ...
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Depending on the chemical nature of the antigens, blood types have different levels of hypersensitivity; for instance, A and B are more antigenic than other antigens. [10] Type II hypersensitivity. Damage can be accomplished via three different mechanisms: [10] Antibody binding to cell surface receptors and altering its activity
Beyond your own to-do list, it's easy to overcommit to social events or take on extra responsibilities, but sometimes, saying no is essential for your well-being. Consider it a gift to yourself. 3.