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[1] [2] The symptoms usually appear during or after a first pregnancy with the most common complaint being severe back pain [3] The exact causes of the disease are not yet known, and most women with PLO have no known predisposing cause of osteoporosis or bone fragility.
During pregnancy the plasma volume increases by 40-50% and the red blood cell volume increases only by 20–30%. [22] These changes occur mostly in the second trimester and prior to 32 weeks gestation. [24] Due to dilution, the net result is a decrease in hematocrit or hemoglobin, which are measures of red blood cell concentration.
Bone tissue is a dynamic system with active metabolism. [24] Bone tissue remodelling or bone remodeling is a successive chain of old bone matrix removal and its replacement with a new one. [25] These processes make a child’s skeleton grow and extend, while childhood is characterized by bone tissue growth rather than its resorption.
Calcification can manifest itself in many ways in the body depending on the location. In the pulpal structure of a tooth, calcification often presents asymptomatically, and is diagnosed as an incidental finding during radiographic interpretation. Individual teeth with calcified pulp will typically respond negatively to vitality testing; te
Dense scars may undergo hyaline degeneration and calcification.; Atheroma in aorta and coronaries frequently undergo calcification. [3] [4]Cysts can show calcification.; Calcinosis cutis is condition in which there are irregular nodular deposits of calcium salts in skin and subcutaneous tissue.
Bone loss increases after menopause in women due to lower levels of estrogen, and after andropause in older men due to lower levels of testosterone. [10] Osteoporosis may also occur due to a number of diseases or treatments, including alcoholism , anorexia , hyperthyroidism , kidney disease , and after oophorectomy (surgical removal of the ...
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