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Meloxicam use can result in gastrointestinal toxicity and bleeding, headaches, rash, and very dark or black stool (a sign of intestinal bleeding). It has fewer gastrointestinal side effects than diclofenac , [ 17 ] piroxicam , [ 18 ] naproxen , [ 19 ] and perhaps all other NSAIDs which are not COX-2 selective.
In the United States, meloxicam is approved for use only in canines, whereas (due to concerns about liver damage) it carries warnings against its use in cats [169] [170] except for one-time use during surgery. [171] In spite of these warnings, meloxicam is frequently prescribed "off-label" for non-canine animals including cats and livestock ...
Complications increase when the initial cause of the liver damage is still present. [12] Liver damage can be caused by viruses, alcohol, medications, and other hepatotoxins. [12] Acetaminophen, found in many prescription and over-the-counter medications, is the most common drug that can cause liver damage if taken in a high dose or in ...
Data from the Drug Induced Liver Injury Network show that rates of liver injury from botanical products jumped from seven percent in 2004-2005 to 20 percent in 2013-2014.
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Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents.
Common causes of this type of injury are blunt force mechanisms such as motor vehicle accidents, falls, and sports injuries. Typically these blunt forces dissipate through and around the structure of the liver [3] and causes irreparable damage to the internal microarchitecture of the tissue. [4]
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