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  2. A scientist who studies the link between our gut and brain ...

    www.aol.com/scientist-studies-between-gut-brain...

    Experts are increasingly questioning the idea that depression, for instance, is solely caused by low serotonin levels, instead believing it is linked to a combination of biological, genetic ...

  3. Serotonin - Wikipedia

    en.wikipedia.org/wiki/Serotonin

    Serotonin (/ ˌ s ɛr ə ˈ t oʊ n ɪ n, ˌ s ɪər ə-/) [6] [7] [8] or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.Its biological function is complex, touching on diverse functions including mood, cognition, reward, learning, memory, and numerous physiological processes such as vomiting and vasoconstriction.

  4. Pharmacology of antidepressants - Wikipedia

    en.wikipedia.org/wiki/Pharmacology_of...

    Serotonin levels in the human brain is measured indirectly by sampling cerebrospinal fluid for its main metabolite, 5-hydroxyindole-acetic acid, or by measuring the serotonin precursor, tryptophan. In one placebo controlled study funded by the National Institute of Health, tryptophan depletion was achieved, but they did not observe the ...

  5. Biology of depression - Wikipedia

    en.wikipedia.org/wiki/Biology_of_depression

    The observation of this efficacy led to the monoamine hypothesis of depression, which postulates that the deficit of certain neurotransmitters is responsible for depression, and even that certain neurotransmitters are linked to specific symptoms. Normal serotonin levels have been linked to mood and behaviour regulation, sleep, and digestion ...

  6. 5-HT1A receptor - Wikipedia

    en.wikipedia.org/wiki/5-HT1A_receptor

    15550 Ensembl ENSG00000178394 ENSMUSG00000021721 UniProt P08908 Q64264 RefSeq (mRNA) NM_000524 NM_008308 RefSeq (protein) NP_000515 NP_032334 Location (UCSC) Chr 5: 63.96 – 63.96 Mb Chr 13: 105.58 – 105.58 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The serotonin 1A receptor (or 5-HT 1A receptor) is a subtype of serotonin receptors, or 5-HT receptors, that binds serotonin ...

  7. No ‘clear evidence’ depression is caused by low serotonin levels

    www.aol.com/no-clear-evidence-depression-caused...

    NHS figures show that the number of people in England taking antidepressants continues to rise, with 8.3m patients receiving them in 2021/22.

  8. 5-HT receptor - Wikipedia

    en.wikipedia.org/wiki/5-HT_receptor

    5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. [ 1 ] [ 2 ] [ 3 ] They mediate both excitatory and inhibitory neurotransmission .

  9. KM-391 - Wikipedia

    en.wikipedia.org/wiki/KM-391

    KM-391 was able to restore brain serotonin concentrations to near-normal levels, restore normal behaviors, and increase neuroplasticity. [3] Moreover, it was more efficacious than fluoxetine in this model. [ 3 ]