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S. pyogenes is the cause of many human diseases, ranging from mild superficial skin infections to life-threatening systemic diseases. [2] The most frequent manifestations of disease are commonly known as scarlet fever. Infections typically begin in the throat or skin. The most striking sign is a strawberry-like rash.
Group A β-hemolytic streptococcus can cause infections of the throat and skin. [6] These may vary from very mild conditions to severe, life-threatening diseases. Although it is not completely clear what causes different people to develop different diseases as a result of infection with the same pathogenic bacteria , it is suspected that host ...
Major endogenous pyrogens are interleukin 1 (α and β) [95]: 1237–1248 and interleukin 6 (IL-6). [96] Minor endogenous pyrogens include interleukin-8, tumor necrosis factor-β, macrophage inflammatory protein-α and macrophage inflammatory protein-β as well as interferon-α, interferon-β, and interferon-γ.
Similar to how Omega-3-packed foods may boost cholesterol, menu items with “good” fats (like legumes, salmon, etc.) may help reduce diseases that cause chronic inflammation. You Might Also Like
Inflammation goes from helpful to harmful when it becomes chronic. Over time, being in a constant inflammatory state can start to damage healthy cells and increase your risk for certain diseases ...
It is the cause of 15–40% of sore throats among children [7] [13] and 5–15% among adults. [8] Cases are more common in late winter and early spring. [13] Potential complications include rheumatic fever and peritonsillar abscess. [1] [2]
SpeB was identified in 1919 as an ectoenzyme secreted by certain strains of streptococci. [11] It was originally studied as two separate toxins, streptococcal pyrogenic exotoxin B and streptococcal cysteine proteinase, until it was shown that both proteins were encoded by the speB gene and that the attributed pyrogenic activities were due to contamination by SpeA and SpeC.
Depyrogenation refers to the removal of pyrogens from solutions, most commonly from injectable pharmaceuticals. A pyrogen is defined as any substance that can cause a fever. Bacterial pyrogens include endotoxins and exotoxins, although many pyrogens are endogenous to the host.