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Lateral inhibition is described as a part of the Notch signaling pathway, a type of cell–cell interaction. Specifically, during asymmetric cell division one daughter cell adopts a particular fate that causes it to be copy of the original cell and the other daughter cell is inhibited from becoming a copy.
One is the "lateral inhibition", which specifies some cells for a primary fate but others for a secondary fate among cells that have the potential to adopt the same fate. Lateral inhibition is required for many types of cell fate determination. Here, it could explain the dispersed distribution of endocrine cells within pancreatic epithelium. [115]
Stem cell differentiation and Notch-Delta lateral inhibition in neural stem cells, resulting in the generation of neuronal and glia progenitors. Notch signaling is known to mediate prominent cellular events that result in gliogenesis. The Notch family proteins are transmembrane receptors that are ligand activated.
EGF repeats 11-12 on the Notch extracellular domain have been shown to be necessary and sufficient for trans signaling interactions between Notch and its ligands. [38] Additionally, EGF repeats 24-29 have been implicated in inhibition of cis interactions between Notch and ligands co-expressed in the same cell. [39]
Lateral inhibition process -The expression of proneural genes in a neural progenitor leads to gliogenesis, neurogenesis and cell-cycle arrest. Besides this, it also promotes the expression of Delta that binds to the Notch receptor of a neighbour cell, repressing the proneural genes.
4854 18131 Ensembl ENSG00000074181 ENSMUSG00000038146 UniProt Q9UM47 Q61982 RefSeq (mRNA) NM_000435 NM_008716 RefSeq (protein) NP_000426 NP_032742 Location (UCSC) Chr 19: 15.16 – 15.2 Mb Chr 17: 32.34 – 32.39 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Neurogenic locus notch homolog protein 3 (Notch 3) is a protein that in humans is encoded by the NOTCH3 gene. Function This ...
3280 15205 Ensembl ENSG00000114315 ENSMUSG00000022528 UniProt Q14469 P35428 RefSeq (mRNA) NM_005524 NM_008235 RefSeq (protein) NP_005515 NP_032261 Location (UCSC) Chr 3: 194.14 – 194.14 Mb Chr 16: 29.88 – 29.89 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transcription factor HES1 (hairy and enhancer of split-1) is a protein that is encoded by the Hes1 gene, and is the ...
Experimental evidence shows that LIN-12 is necessary and sufficient for the formation of the 2° fate. Through lateral inhibition LIN-12 prevents the P5.p and P7.p cells from adopting the 1° lineage. [7] Thus, in this example both inductive EGF signaling and lateral Notch activation pattern the VPC equivalence group.