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HBTU (Hexafluorophosphate Benzotriazole Tetramethyl Uronium) is a coupling reagent used in solid phase peptide synthesis. It was introduced in 1978 and shows resistance against racemization. It was introduced in 1978 and shows resistance against racemization.
Coupling reagents (e.g. HBTU, HATU, or DIC) are employed to help form the peptide bond. The final deprotection is followed by a cleavage. The established method for the production of synthetic peptides in the lab is known as solid phase peptide synthesis (SPPS). [2]
HBTU is a government-aided state-university for technical UG and PG education specialising in engineering and technology. It is a non-collegiate unitary-type university, and does not affiliate or administer other colleges or institutes.
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2011-05-20 22:10 AlexNB 453×194× (39518 bytes) Chemicl structures of several commonly used uronium-based peptide coupling reagents: HATU, HBTU, HCTU, COMU. Captions English
HCTU is an amidinium coupling reagent used in peptide synthesis.It is analogous to HBTU. [1] The HOBt moiety has a chlorine in the 6 position which improves reaction rates and the synthesis of difficult couplings [2] [3] HCTU and related reagents containing the 6-chloro-1-hydroxybenzotriazole moiety can be prepared by reaction with TCFH under basic conditions. [4]