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Since untreated feline infectious peritonitis (FIP) is fatal in almost all cases [9] and in most countries there are no approved treatments available, GS-441524 has reportedly been sold illegally worldwide on the black market and used by pet owners to treat affected cats, although Gilead Sciences has refused to license the drug for veterinary use.
There is a lack of evidence that FIP as such is transmissible from cat to cat, although it may explain rare mini-outbreaks of FIP. [8] However, the virus, FCov, is transmissible from cat to cat. A study on 59 FIP infected cats found that, unlike FCoV, feces from FIP infected cats were not infectious to laboratory cats via oronasal route. [9]
Feline diseases are often opportunistic and tend to be more serious in cats that already have concurrent sicknesses. Some of these can be treated and the animal can have a complete recovery. Others, like viral diseases, are more difficult to treat and cannot be treated with antibiotics, which are not effective against viruses.
Cat owners can rejoice, as a medication that can treat a fairly deadly illness will be available in the United States from June 1. Feline infectious peritonitis (FIP) is a viral disease that can ...
FIPV causes feline infectious peritonitis, for which treatment is generally symptomatic and palliative only. The drug GS-441524 shows promise as an antiviral treatment for FIP, but at the moment it still requires further research. [4] The drug GC376 is also being studied and developed.
It is particularly used for infections of the skin, respiratory system and mammary glands in dogs and cats, as well as with urinary tract infections. For dogs, a dose ranges from 2.75 - 5.5 mg/kg once a day. The duration of treatment is usually at least five days, longer if there is a concurrent fungal or yeast infection. [4]
The utility of targeting the 3CL protease in a real world setting was first demonstrated in 2018 when GC376 (a prodrug of GC373) was used to treat the previously 100% lethal cat coronavirus disease, feline infectious peritonitis, caused by feline coronavirus. [12]
Side effects include hyperthermia and decrease in white blood cell count. These effects tend to be mild and transient. It is a immunostimulant in the interferon family. [3] The feline interferon "omega" gene was first cloned in 1992. [4] It was first produced in silkworms by Ueda and coworkers in 1993.