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C3 convertase (C4bC2b, formerly C4b2a) belongs to family of serine proteases and is necessary in innate immunity as a part of the complement system which eventuate in opsonisation of particles, release of inflammatory peptides, C5 convertase formation and cell lysis.
LAX serves as a major hub or focus city for seven airlines, more than any other airport in the United States. In 2019, LAX handled over 88 million passengers and 2 million tons of cargo. [2] The FlyAway express bus system connects LAX with Los Angeles Union Station, the region's primary rail transportation hub.
The airport meets modified FAA D-III airport reference code standards. On April 4, 2011, the airport began a $15.5 million runway extension project which added 1,000 feet of runway length to the existing runway, bringing the total length to 8,006 ft (2,440 m). This project was completed on November 2, 2011. [9]
LAX is located in the Westchester neighborhood of the city of Los Angeles, 18 miles (29 km; 16 nmi) southwest of downtown Los Angeles, with the commercial and residential areas of Westchester to the north, the city of El Segundo to the south, and the city of Inglewood to the east. LAX is the closest airport to the Westside and the South Bay.
The basic layout of the airport dates back to 1958 when the architecture firm Pereira & Luckman was contracted to plan the re-design of the airport for the "jet age."The plan, developed with architects Welton Becket and Paul Williams, called for a series of terminals and parking structures in the central portion of the property, with these buildings connected at the center by a huge steel-and ...
On April 29, 1992, the airport closed for cleanup after the 1992 Los Angeles Riots over the Rodney King beating. [citation needed] The airport closed again as a 2-hour precaution on January 17, 1994 after the Northridge earthquake. [citation needed] In 1996, a $29 million, 277-foot-tall (84 m) air traffic control tower was built near the Theme ...
C2b diffuses into the plasma as a protein inflammatory mediator while C2a remains attached with C4b, forming the C3-convertase (C4b2a). The function of the membrane-bound C3-convertase is the cleavage of many many molecules of C3 into C3a and C3b. C3a is a smaller fragment of C3 is a potent inflammatory mediator.
Bb remains bound to C3(H 2 O) to form C3(H 2 O)Bb. This complex is also known as a fluid-phase C3-convertase. This convertase, the alternative pathway C3-convertase, although only produced in small amounts, can cleave multiple C3 proteins into C3a and C3b. The complex is believed to be unstable until it binds properdin, a serum protein. The ...
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