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Common side effects of senna glycoside include abdominal cramps. [3] It is not recommended for long-term use, as it may result in poor bowel function or electrolyte problems. [1] While no harm has been found to result from use while breastfeeding, such use is not typically recommended. [1] It is not typically recommended in children. [1]
Senna plant. Properties. Site of action: colon; Onset of action: 6–10 hours; Examples: senna, bisacodyl [3] Prolonged use of stimulant laxatives can create drug dependence by damaging the colon's haustral folds, making users less able to move feces through their colon on their own. A study of patients with chronic constipation found that 28% ...
Side effects are uncommon and typically mild, [1] and may include stomach pain, abdominal cramps or diarrhea, [1] Efficacy decreases with long-term use, and may cause poor bowel function. [9] Serious allergic reactions may occur with the drug. The most severe side effect of docusate, although very rare, is rectal bleeding. [23]
He says that fiber supplements, such as psyllium, are an excellent second-line option for managing constipation. Laxatives can also be used, short-term, if needed. Examples include:
There are no known drug interactions, although as a stimulant laxative it may affect how long a medicine remains in the digestive tract. It is best not to take senna within 1 to 2 hours of taking other medicines.
The dosage of lactulose for chronic idiopathic constipation is adjusted depending on the constipation severity and desired effect, from a mild stool softener to causing diarrhea. Lactulose is contraindicated in case of galactosemia , as most preparations contain the monosaccharide galactose due to its synthesis process.