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The induction phase includes exposing a test group of animals twice to the test material, first by intradermal injection followed by topical application seven days later. During Induction A, the test animals are exposed intradermally to the test material, along with an adjuvant to enhance the immune reaction of the guinea pig. During Induction ...
A subject of the Tuskegee syphilis experiment has his blood drawn, c. 1953.. Numerous experiments which were performed on human test subjects in the United States in the past are now considered to have been unethical, because they were performed without the knowledge or informed consent of the test subjects. [1]
Human subject research is systematic, scientific investigation that can be either interventional (a "trial") or observational (no "test article") and involves human beings as research subjects, commonly known as test subjects. Human subject research can be either medical (clinical) research or non-medical (e.g., social science) research. [1]
The Buehler test is an in vivo test to screen for substances that cause human skin sensitisation (i.e. allergens). It was first proposed by Edwin Vernon Buehler in 1965 [1] and further explained in 1980. [2] It is a non-adjuvant test. In the test, guinea pigs are exposed to a high dose of the substance.
A faction of the Civilian Public Service camps developed into a scientific research unit known as Camp #115, or the “Guinea pig units.” [39] These units included around 500 conscientious objectors who volunteered to be scientific test subjects in a wide range of human medical experiments in the country's top universities and hospitals. [40]
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Human Guinea Pigs: Experimentation on Man is a book about unethical human experimentation, written by Maurice Pappworth and published by Routledge and Kegan Paul in 1967. In the 1970s the book prompted a change in the regulation of human research.
Maurice Henry Papperovitch was born on 9 January 1910, [nb 1] Pappworth was the seventh child in a family that included three sons and six daughters. [1] He graduated MB ChB (Hons) (Bachelor of Medicine and Bachelor of Surgery with honours) from Liverpool University's medical school in 1932 [2] after previously studying at the Birkenhead Institute.