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Cell culture of granulosa cells can be performed in vitro. Plating density (number of cells per volume of culture medium) plays a critical role for the differentiation. A lower plating density makes granulosa cells exhibit estrogen production, while a higher plating density makes them appear as progesterone producing theca lutein cells. [12]
The enzyme aromatase can be found in many tissues including gonads (granulosa cells), brain, adipose tissue, placenta, blood vessels, skin, and bone, as well as in tissue of endometriosis, uterine fibroids, breast cancer, and endometrial cancer. [citation needed] It is an important factor in sexual development.
Pinealocytes are the main cells contained in the pineal gland, located behind the third ventricle and between the two hemispheres of the brain.The primary function of the pinealocytes is the secretion of the hormone melatonin, important in the regulation of circadian rhythms. [1]
David Marr and James Albus suggested that the cerebellum operates as an adaptive filter, altering motor behaviour based on the nature of the sensory input. Since multiple (~200,000) granule cells synapse onto a single Purkinje cell, the effects of each parallel fiber can be altered in response to a “teacher signal” from the climbing fiber ...
Hormones can be amino acid complexes, steroids, eicosanoids, leukotrienes, or prostaglandins. [3] The endocrine system is contrasted both to exocrine glands, which secrete hormones to the outside of the body, and to the system known as paracrine signalling between cells over a relatively short distance.
The anterior pituitary complex and hypophyseal portal system, where FSH and LH are released. Theca cells are responsible for synthesizing androgens, providing signal transduction between granulosa cells and oocytes during development by the establishment of a vascular system, providing nutrients, and providing structure and support to the follicle as it matures.
HPG regulation in males, with the inhibin/activin system playing a similar role on GnRH-producing cells. The hypothalamus is located in the brain and secretes GnRH. [1] GnRH travels down the anterior portion of the pituitary via the hypophyseal portal system and binds to receptors on the secretory cells of the adenohypophysis. [2]
The secretion of aldosterone is also stimulated by adrenocorticotropic hormone (ACTH). [8] The cells of the zona glomerulosa do not express 11β-hydroxylase and 17α-hydroxylase. This is the reason zona glomerulosa cannot synthesize cortisol, corticosterone, or sex hormones . [9]