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Zidovudine (ZDV), also known as azidothymidine (AZT), was the first antiretroviral medication used to prevent and treat HIV/AIDS. It is generally recommended for use in combination with other antiretrovirals. [ 6 ]
Lamivudine/zidovudine, sold under the brand name Combivir among others, is a fixed-dose combination antiretroviral medication used to treat HIV/AIDS. [2] It contains two antiretroviral medications , lamivudine and zidovudine . [ 2 ]
Zidovudine, also called AZT, ZDV, and azidothymidine, has the trade name Retrovir. Zidovudine was the first antiretroviral drug approved by the FDA for the treatment of HIV. Didanosine, also called ddI, with the trade names Videx and Videx EC, was the second FDA-approved antiretroviral drug. It is an analog of adenosine.
In 1974 zidovudine was reported to have activity against retroviruses and was subsequently re-screened as an antiviral when the AIDS epidemic hit Western societies during the mid-1980s. [ 13 ] [ 15 ] However, zidovudine is relatively toxic since it is converted into the triphosphate by the cellular enzymes and therefore it is activated in ...
In the UK, there is 11.8% medium to high-level resistance at baseline to the combination of efavirenz + zidovudine + lamivudine, and 6.4% medium to high level resistance to stavudine + lamivudine + nevirapine. [49] In the US, 10.8% of one cohort of patients who had never been on ART before had at least one resistance mutation in 2005. [50]
Zidovudine: HIV [23] Antiretroviral References This page was last edited on 24 January 2025, at 04:09 (UTC). Text is available under the Creative Commons ...
zidovudine (AZT or ZDV) It is indicated in the treatment of AIDS/HIV -1. [ 2 ] For this purpose, the combination is very useful in pregnant women to decrease the risk of mother-to-child transmission .
It contains lamivudine, nevirapine, and zidovudine. [2] It is either used by itself or along with other antiretrovirals . [ 2 ] It is a recommended treatment in those who are pregnant . [ 2 ]