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Augmentin 250, for example, contains 250 mg of amoxicillin and 125 mg of clavulanic acid. [ 12 ] [ 22 ] An intravenous preparation has been available in the UK since 1985, [ 23 ] but no parenteral preparation is available in the US; [ citation needed ] the nearest equivalent is ampicillin/sulbactam .
Clavulanic acid. Clavulanic acid is a β-lactam drug that functions as a mechanism-based β-lactamase inhibitor. While not effective by itself as an antibiotic, when combined with penicillin -group antibiotics, it can overcome antibiotic resistance in bacteria that secrete β-lactamase, which otherwise inactivates most penicillins.
Amoxicillin (α-amino- p -hydroxybenzyl penicillin) is a semisynthetic derivative of penicillin with a structure similar to ampicillin but with better absorption when taken by mouth, thus yielding higher concentrations in blood and in urine. [ 50 ] Amoxicillin diffuses easily into tissues and body fluids.
Generic name Brand names Common uses [4] Possible side effects [4] Mechanism of action Aminoglycosides; Amikacin: Amikin: Infections caused by Gram-negative bacteria, such as Escherichia coli and Klebsiella particularly Pseudomonas aeruginosa. Effective against aerobic bacteria (not obligate/facultative anaerobes) and tularemia. All ...
Cloxacillin. Cloxacillin is an antibiotic useful for the treatment of a number of bacterial infections. [1] This includes impetigo, cellulitis, pneumonia, septic arthritis, and otitis externa. [1] It is not effective for methicillin-resistant Staphylococcus aureus (MRSA). [2] It can be used by mouth and by injection.
The β-lactam core structures. (A) A penam.(B) A carbapenam.(C) An oxapenam.(D) A penem.(E) A carbapenem.(F) A monobactam.(G) A cephem.(H) A carbacephem.(I) An oxacephem. This is a list of common β-lactam antibiotics—both administered drugs and those not in clinical use—organized by structural class.
Ampicillin is an antibiotic belonging to the aminopenicillin class of the penicillin family. The drug is used to prevent and treat a number of bacterial infections, such as respiratory tract infections, urinary tract infections, meningitis, salmonellosis, and endocarditis. [7]
An example is clavulanic acid, [4] from which this compound class receives its name. Clavulanic acid, a type of clavam, has antibiotic properties. It can be used as a medication to treat a variety of bacterial infections. Clavam tablets may be effective for short-term treatment of bronchitis, cystitis, sinusitis, otitis media, or skin infections.