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The SOS response is a global response to DNA damage in which the cell cycle is arrested and DNA repair and mutagenesis are induced. The system involves the RecA protein ( Rad51 in eukaryotes). The RecA protein, stimulated by single-stranded DNA, is involved in the inactivation of the repressor ( LexA ) of SOS response genes thereby inducing the ...
DNA repair is a collection of processes by which a cell ... and other bacteria in response to extensive DNA damage. The prokaryotic SOS system is regulated ...
The dimerization domain binds to other LexA polypeptides to form dumbbell shaped dimers. The DNA-binding domain is a variant form of the helix-turn-helix DNA binding motif, [4] and is usually located at the N-terminus of the protein. [1] This domain is bound to an SOS box upstream of SOS response genes until DNA damage stimulates ...
In this case, the term PRR would encompasses all processes that facilitate the replication of damaged DNA, including those that repair replication-induced double-strand breaks. Melanoma cells are commonly defective in postreplication repair of DNA damages that are in the form of cyclobutane pyrimidine dimers , a type of damage caused by ...
[3] [4] RecA serves as an archetype for this class of homologous DNA repair proteins. The homologous protein is called RAD51 in eukaryotes and RadA in archaea. [5] [6] RecA has multiple activities, all related to DNA repair. In the bacterial SOS response, it has a co-protease [7] function in the autocatalytic cleavage of the LexA repressor and ...
SOS box is the operator to which the LexA repressor binds to repress the transcription of SOS-induced proteins. SOS boxes are found near the promoter of various genes. [1] LexA binds to an SOS box in the absence of DNA damage. In the presence of DNA damage the binding of LexA is inactivated by the RecA activator.
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Radman's specialty is DNA repair.His work with Evelyn M. Witkin set the basis for the discovery of the SOS response.The SOS response hypothesis was put forward by Radman in 1970 in a letter sent to various researchers, and later published in 1974.