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Replication (statistics) In engineering, science, and statistics, replication is the process of repeating a study or experiment under the same or similar conditions to support the original claim, which crucial to confirm the accuracy of results as well as for identifying and correcting the flaws in the original experiment. [1]
The replication fork is a structure that forms within the long helical DNA during DNA replication. It is produced by enzymes called helicases that break the hydrogen bonds that hold the DNA strands together in a helix. The resulting structure has two branching "prongs", each one made up of a single strand of DNA.
The replication crisis[a] is an ongoing methodological crisis in which the results of many scientific studies are difficult or impossible to reproduce. Because the reproducibility of empirical results is an essential part of the scientific method, [2] such failures undermine the credibility of theories building on them and potentially call into ...
The origin of replication (also called the replication origin) is a particular sequence in a genome at which replication is initiated. [1] Propagation of the genetic material between generations requires timely and accurate duplication of DNA by semiconservative replication prior to cell division to ensure each daughter cell receives the full ...
Reproducibility, closely related to replicability and repeatability, is a major principle underpinning the scientific method.For the findings of a study to be reproducible means that results obtained by an experiment or an observational study or in a statistical analysis of a data set should be achieved again with a high degree of reliability when the study is replicated.
Ligases are particularly important in lagging strand DNA replication, as they join the short segments of DNA produced at the replication fork into a complete copy of the DNA template. They are also used in DNA repair and genetic recombination .
Eukaryotic DNA replication is a conserved mechanism that restricts DNA replication to once per cell cycle. Eukaryotic DNA replication of chromosomal DNA is central for the duplication of a cell and is necessary for the maintenance of the eukaryotic genome. DNA replication is the action of DNA polymerases synthesizing a DNA strand complementary ...
S phase. Asymmetry in the synthesis of leading and lagging strands. S phase (Synthesis phase) is the phase of the cell cycle in which DNA is replicated, occurring between G 1 phase and G 2 phase. [ 1 ] Since accurate duplication of the genome is critical to successful cell division, the processes that occur during S-phase are tightly regulated ...