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Verapamil, sold under various trade names, [1] is a calcium channel blocker medication used for the treatment of high blood pressure, angina (chest pain from not enough blood flow to the heart), and supraventricular tachycardia. [9] It may also be used for the prevention of migraines and cluster headaches.
[2] [49] Verapamil was previously underused in people with cluster headache. [8] Improvement can be seen in an average of 1.7 weeks for episodic cluster headache and 5 weeks for chronic cluster headache when using a dosage of ranged between 160 and 720 mg (mean 240 mg/day). [ 50 ]
Skeletal formula of verapamil. Phenylalkylamine calcium channel blockers are relatively selective for myocardium, reduce myocardial oxygen demand and reverse coronary vasospasm, and are often used to treat angina.
Abortive therapy for cluster headaches includes subcutaneous sumatriptan (injected under the skin) and triptan nasal sprays. High flow oxygen therapy also helps with relief. [11] For people with extended periods of cluster headaches, preventive therapy can be necessary. Verapamil is recommended as first line treatment. Lithium can also be useful.
SUNCT must be properly distinguished from cluster headaches, since cluster headaches also occur several times per day with separate attacks, and share some common symptoms. However, cluster headaches usually last longer (up to three hours), occur less often (three to five attacks per day), and do not accompany cranial autonomic symptoms.
Under "Prevention," the entry now states: >>The recommended first-line preventative therapy is verapamil, calcium channel blocker.[3][35] Despite its usefulness, only four percent of people with cluster headache report verapamil use.[5]<< I suppose that first sentence is supposed to say "a calcium channel blocker," but my concern is with the ...
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