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SLE is regarded as a prototype disease due to the significant overlap in its symptoms with other autoimmune diseases. [75] Patients with SLE have higher levels of DNA damage than normal subjects, and several proteins involved in the preservation of genomic stability show polymorphisms, some of which increase the risk for SLE development. [76]
Childhood-onset systemic lupus erythematosus (i.e., cSLE), also termed juvenile-onset systemic lupus erythematosus, juvenile systemic lupus erythematosus, and pediatric systemic lupus erythematosus, is a form of the chronic inflammatory and autoimmune disease, systemic lupus erythematosus (i.e., SLE), that develops in individuals up to 18 years old. [1]
Females in the UK are seven times more likely to be diagnosed with SLE than males. [24] The estimated number of females in the UK with SLE is 21,700, and the number of males is 3000 — a total of 24,700, or 0.041% of the population. [24] SLE is more common amongst certain ethnic groups than others, especially those of African origin. [24]
SLE systemic lupus erythematosus soln solution sp species singular spp species plural sp gr specific gravity sq square SSRI selective serotonin reuptake inhibitor STS serologic test(s) for syphilis T&A tonsillectomy and adenoidectomy TB tuberculosis tds 3 times a day tid preferred in some regions TIBC total iron-binding capacity
Discoid lupus erythematosus is the most common type of chronic cutaneous lupus (CCLE), an autoimmune skin condition on the lupus erythematosus spectrum of illnesses. [1] [2] It presents with red, painful, inflamed and coin-shaped patches of skin with a scaly and crusty appearance, most often on the scalp, cheeks, and ears.
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Neuropsychiatric systemic lupus erythematosus or NPSLE refers to the neurological and psychiatric manifestations of systemic lupus erythematosus.SLE is a disease in which the immune system attacks the body's own cells and tissues.
[1]: 212 This test can be helpful in distinguishing systemic lupus erythematosus (SLE) from cutaneous lupus, because in SLE the lupus band test will be positive in both involved and uninvolved skin, whereas with cutaneous lupus only the involved skin will be positive. [1]: 212 The minimum criteria for positivity are: [2]