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Positive α-Synuclein staining of a Lewy body from a patient who had Parkinson's disease. Alpha synuclein, having no single, well-defined tertiary structure, is an intrinsically disordered protein, [77] [78] with a pI value of 4.7, [79] which, under certain pathological conditions, can misfold in a way that exposes its core hydrophobic residues ...
The DNA repair function of alpha-synuclein appears to be compromised in Lewy body inclusion bearing neurons, and this may trigger cell death. Study of synucleinopathy mouse models of Parkinson's disease indicates that alpha-synuclein pathogenesis is associated with increased DNA damage and activation of the DNA damage response. [19]
Stains used: mouse monoclonal alpha-synuclein antibody; counterstained with Mayer's haematoxylin Lewy bodies Lewy bodies are the inclusion bodies – abnormal aggregations of protein – that develop inside neurons affected by Parkinson's disease (PD), the Lewy body dementias ( Parkinson's disease dementia and dementia with Lewy bodies (DLB ...
Studies have suggested that aggregations of a protein — alpha synuclein — in the brain form Lewy bodies, and lead to the loss of dopaminergic neurons, a key feature of Parkinson’s disease ...
Positive Alpha-Synuclein staining of a Lewy body in a patient with Parkinson's disease. Braak staging refers to two methods used to classify the degree of pathology in Parkinson's disease and Alzheimer's disease. These methods are used both in research and for the clinical diagnosis of these diseases and are obtained by performing an autopsy of ...
Alpha-synuclein (α-synuclein) is an endogenous protein that is encoded by the SNCA gene and known as the pathological hallmark of Parkinson's disease. [13] It is found in distinct regions of the body, but in PD, alpha-synuclein accumulation in the brain is of main importance.
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