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Gene therapy for epilepsy consists of employing vectors to deliver pieces of genetic material to areas of the brain involved in seizure onset. [77] Seizure prediction is a special case of seizure detection in which the developed systems are able to issue a warning before the clinical onset of the epileptic seizure. [76] [78]
Plates vi & vii of the Edwin Smith Papyrus (around the 17th century BC), among the earliest medical guidelines. A medical guideline (also called a clinical guideline, standard treatment guideline, or clinical practice guideline) is a document with the aim of guiding decisions and criteria regarding diagnosis, management, and treatment in specific areas of healthcare.
Epilepsy is a group of non-communicable neurological disorders characterized by recurrent epileptic seizures. [10] An epileptic seizure is the clinical manifestation of an abnormal, excessive, and synchronized electrical discharge in the neurons. [1] The occurrence of two or more unprovoked seizures defines epilepsy. [11]
According to guidelines by the American Academy of Neurology and American Epilepsy Society, [42] mainly based on a major article review in 2004, [43] patients with newly diagnosed epilepsy who require treatment can be initiated on standard anticonvulsants such as carbamazepine, phenytoin, valproic acid/valproate semisodium, phenobarbital, or on ...
Tonic–clonic seizures are the seizure type most commonly associated with epilepsy and seizures in general and the most common seizure associated with metabolic imbalances. [2] It is a misconception that they are the sole type of seizure, as they are the main seizure type in approximately 10% of those with epilepsy.
If the abnormal brain wave activity is persistent and results from ongoing seizures, then a diagnosis of myoclonic epilepsy may be considered. [1] Familial adult myoclonus Epilepsy (FAME) This is a condition characterized by the repetition of non-coding sequences and has been identified using various abbreviations. Initially, it was associated ...
Their purpose is to engage clinicians in systematic evaluation of their clinical practice against standards (often set by NICE), and to encourage improvement in the quality of care. This programme is gradually being extended to other areas of healthcare, working with clinical, patient and professional advisory groups.
The prevalence of epilepsy in Maharashtra is estimated to be 1 million people. Epilepsy Foundation of India [32] has been providing free diagnosis and treatment to people living with epilepsy across rural Maharashtra since 2011. Since 2018, they have been using MedEngage services to collect PROs from thousands of patients across the state.