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Free Radical Biology and Medicine is a peer-reviewed scientific journal and official journal of the Society for Redox Biology and Medicine.The journal covers research on redox biology, signaling, biological chemistry and medical implications of free radicals, reactive species, oxidants and antioxidants.
A free radical is any atom or molecule that has a single unpaired electron in an outer shell. [2] While a few free radicals such as melanin are not chemically reactive, most biologically relevant free radicals are highly reactive. [3] For most biological structures, free radical damage is closely associated with oxidative damage.
Redox Biology is an open-access peer-reviewed scientific journal and an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe. [ 1 ] [ 2 ] The journal covers research on redox biology, aging, signaling, biological chemistry and medical implications of free radicals for health and disease.
Free radicals are reactive molecules produced by cellular and environmental processes, and can damage the elements of the cell such as the cell membrane and DNA and cause irreversible damage. The free-radical theory of aging proposes that this damage cumulatively degrades the biological function of cells and impacts the process of aging. [18]
Hydroxyl radicals can attack the deoxyribose DNA backbone and bases, potentially causing a plethora of lesions that can be cytotoxic or mutagenic. Cells have developed complex and efficient repair mechanisms to fix the lesions. In the case of free radical attack on DNA, base-excision repair is the repair mechanism used. Hydroxyl radical ...
The mitochondrial theory of ageing has two varieties: free radical and non-free radical. The first is one of the variants of the free radical theory of ageing. It was formulated by J. Miquel and colleagues in 1980 [1] and was developed in the works of Linnane and coworkers (1989). [2] The second was proposed by A. N. Lobachev in 1978. [3]
Free radicals and other reactive species in biological, clinical, environmental and other systems; Antioxidants, including diet-derived antioxidants and other relevant aspects of human nutrition; Oxidative damage, mechanisms and measurement; Redox signaling
Other free radicals produced within the body are now understood to be more important. His injuries healed later. As a field of medical sciences, radiobiology originated from Leopold Freund 's 1896 demonstration of the therapeutic treatment of a hairy mole using the newly discovered form of electromagnetic radiation called X-rays.