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It is unclear if phytoestrogens have any effect on the cause or prevention of cancer in women. [ 1 ] [ 36 ] Some epidemiological studies have suggested a protective effect against breast cancer. [ 1 ] [ 36 ] [ 37 ] Additionally, other epidemiological studies found that consumption of soy estrogens is safe for patients with breast cancer, and ...
Genistein was found to increase the rate of proliferation of estrogen-dependent breast cancer when not cotreated with an estrogen antagonist. [ 51 ] [ 52 ] [ 53 ] It was also found to decrease efficiency of tamoxifen and letrozole - drugs commonly used in breast cancer therapy.
Staging breast cancer is the initial step to help physicians determine the most appropriate course of treatment. As of 2016, guidelines incorporated biologic factors, such as tumor grade, cellular proliferation rate, estrogen and progesterone receptor expression, human epidermal growth factor 2 (HER2) expression, and gene expression profiling into the staging system.
The American Cancer Society reports 5-year relative survival rates of over 70% for women with stage 0-III breast cancer with a 5-year relative survival rate close to 100% for women with stage 0 or stage I breast cancer. The 5-year relative survival rate drops to 22% for women with stage IV breast cancer. [3]
One of their recent publications was a 2019 meta-analysis of menopausal hormone therapy and breast cancer risk based on type and timing of therapy. [1] In 2012, the group concluded in a meta-analysis of 117 studies that the incidence of breast cancer was increased by each year younger at menarche and each year older at menopause. [4]
8-Prenylnaringenin (8-PN; also known as flavaprenin, (S)-8-dimethylallylnaringenin, hopein, or sophoraflavanone B) is a prenylflavonoid phytoestrogen. It is reported to be the most estrogenic phytoestrogen known. [1] The compound is equipotent at the two forms of estrogen receptors, ERα and ERβ, [2] and it acts as a full agonist of ERα. [3]
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