Search results
Results From The WOW.Com Content Network
Lipophilic antioxidants [3] and iron chelators [1] can prevent ferroptotic cell death. Researchers have identified roles in which oxytosis/ferroptosis can contribute to the medical field, such as the development of cancer therapies. [4] Ferroptosis activation plays a regulatory role on growth of tumor cells in the human body.
Human iron metabolism is the set of chemical reactions that maintain human homeostasis of iron at the systemic and cellular level. Iron is both necessary to the body and potentially toxic. Controlling iron levels in the body is a critically important part of many aspects of human health and disease.
Iron: iron toxicity, iron poisoning, or iron overload is well known. Iron does test only very weakly positive for the Ames test for cancer, however, since it is such a strong catalyst and essential for the production of ATP and consequently DNA production, any excess soluble iron is toxic especially over time. Too much iron deposited in tissues ...
Iron plays an essential role in marine systems and can act as a limiting nutrient for planktonic activity. [51] Because of this, too much of a decrease in iron may lead to a decrease in growth rates in phytoplanktonic organisms such as diatoms. [52] Iron can also be oxidized by marine microbes under conditions that are high in iron and low in ...
In humans, IL-6 production results in low serum iron, making it difficult for invading pathogens to infect. Such iron depletion has been demonstrated to limit bacterial growth in both extracellular and intracellular locations. [47] In addition to "iron withdrawal" tactics, mammals produce an iron –siderophore binding protein, siderochelin.
Iron deficiency, or sideropenia, is the state in which a body lacks enough iron to supply its needs. Iron is present in all cells in the human body and has several vital functions, such as carrying oxygen to the tissues from the lungs as a key component of the hemoglobin protein, acting as a transport medium for electrons within the cells in the form of cytochromes, and facilitating oxygen ...
Get AOL Mail for FREE! Manage your email like never before with travel, photo & document views. Personalize your inbox with themes & tabs. You've Got Mail!
Role in cancer [ edit ] As reviewed by Kovacevic et al., [ 14 ] NDRG1 is a potent, iron-regulated growth and metastasis suppressor that was found to be negatively correlated with cancer progression in a number of tumors, including prostate, pancreatic, breast, and colon cancers.