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  2. Heparin - Wikipedia

    en.wikipedia.org/wiki/Heparin

    Heparin, also known as unfractionated heparin (UFH), is a medication and naturally occurring glycosaminoglycan. [3] [4] Heparin is a blood anticoagulant that increases the activity of antithrombin. [5] It is used in the treatment of heart attacks and unstable angina. [3] It can be given intravenously or by injection under the skin. [3]

  3. Direct thrombin inhibitor - Wikipedia

    en.wikipedia.org/wiki/Direct_thrombin_inhibitor

    Argatroban (as well as the hirudins) is used for heparin-induced thrombocytopenia, a relatively infrequent yet serious complication of heparin treatment that requires anticoagulation (as it increases both arterial and venous thrombosis risk) but not with the causative agent, heparin. [1] Ximelagatran showed good efficacy compared with warfarin ...

  4. Glycosaminoglycan - Wikipedia

    en.wikipedia.org/wiki/Glycosaminoglycan

    Endogenous heparin is localized and stored in secretory granules of mast cells. Histamine that is present within the granules is protonated (H 2 A 2+ ) at pH within granules (5.2–6.0), thus it is believed that heparin, which is highly negatively charged, functions to electrostatically retain and store histamine. [ 13 ]

  5. Thrombosis - Wikipedia

    en.wikipedia.org/wiki/Thrombosis

    Cancer-associated thrombosis can result from: (1) stasis, i.e., direct pressure on blood vessels by the tumor mass, poor performance status, and bed rest following surgical procedures; (2) iatrogenic, due to treatment with antineoplastic medications; and (3) secretion of heparanase from malignant tumors that results in degradation of endogenous ...

  6. Cardiovascular agents - Wikipedia

    en.wikipedia.org/wiki/Cardiovascular_agents

    It is administered intravenously (into a vein) or subcutaneously (below the skin). Heparin can exert an immediate anti-clotting effect which is useful for the treatment of acute symptoms. [36] Besides, heparin therapy is indicated for anticoagulation during pregnancy as it does not cross the placenta and is not associated with fetal malformations.

  7. Type 1 diabetes - Wikipedia

    en.wikipedia.org/wiki/Type_1_diabetes

    Type 1 and 2 diabetes was estimated to cause $10.5 billion in annual medical costs ($875 per month per diabetic) and an additional $4.4 billion in indirect costs ($366 per month per person with diabetes) in the U.S. [138] In the United States $245 billion every year is attributed to diabetes. Individuals diagnosed with diabetes have 2.3 times ...

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