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It appears to be safe during pregnancy but has not been well studied in this group. [8] It is a serotonin 5-HT 3 receptor antagonist. [8] It does not have any effect on dopamine receptors or muscarinic acetylcholine receptor and therefore does not cause akathisia. [11] Ondansetron was patented in 1984 and approved for medical use in 1990. [12]
Women should speak to their doctor or healthcare professional before starting or stopping any medications while pregnant. [1] Drugs taken in pregnancy including over-the counter-medications, prescription medications, nutritional supplements, recreational drugs, and illicit drugs may cause harm to the mother or the unborn child.
Some women choose to have an abortion due to the severity of symptoms. [1] Complications such as Wernicke encephalopathy or esophageal rupture may occur, but very rarely. [1] Taking prenatal vitamins before pregnancy may decrease the risk. [3] Specific treatment other than a bland diet may not be required for mild cases.
HG is estimated to affect 0.3–2.0% of pregnant women, although some sources say the figure can be as high as 3%. [6] [9] [5] While previously known as a common cause of death in pregnancy, with proper treatment this is now very rare. [13] [14] Those affected have a lower risk of miscarriage but a higher risk of premature birth. [15]
5-HT 3 antagonists are most effective in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV), especially that caused by highly emetogenic drugs such as cisplatin; when used for this purpose, they may be given alone or, more frequently, with a glucocorticoid, usually dexamethasone.
The growing popularity of drugs like Ozempic, Mounjaro and Wegovy, designed to help people with Type 2 diabetes and obesity, has raised new questions about what those drugs could mean for ...