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Thiamine acts as an essential cofactor in glucose metabolism, [69] therefore, it may modulate diabetic complications by controlling glycemic status in diabetic patients. [69] [70] Additionally, deficiency of thiamine was observed to be associated with dysfunction of β-cells and impaired glucose tolerance. [70]
Diabetic cheiroarthropathy, also known as diabetic stiff hand syndrome or limited joint mobility syndrome, is a cutaneous condition characterized by waxy, thickened skin and limited joint mobility of the hands and fingers, leading to flexion contractures, a condition associated with diabetes mellitus [1]: 681 and it is observed in roughly 30% of diabetic patients with longstanding disease.
The mean age at presentation is thirty-seven years with a reported range of nineteen to sixty-four years. The mean age of onset since diagnosis of diabetes is fifteen years. The female:male ratio is 1.3:1. Other diabetic complications such as nephropathy, neuropathy, retinopathy and hypertension are usually present. Its major symptom is the ...
Complications may include seizures, disseminated intravascular coagulopathy, mesenteric artery occlusion, or rhabdomyolysis. [2] The main risk factor is a history of diabetes mellitus type 2. [4] Occasionally it may occur in those without a prior history of diabetes or those with diabetes mellitus type 1.
The most frequent cause of hospitalization for diabetic patients is due to foot infections. [3] Symptoms may include pus from a wound, redness, swelling, pain, warmth, tachycardia, or tachypnea. [4] Complications can include infection of the bone, tissue death, amputation, or sepsis. [2] They are common and occur equally frequently in males and ...
A systematic review has found that diabetic peripheral neuropathy affects 30% of diabetes patients. [1] Diabetic neuropathy is implicated in 50–75% of nontraumatic amputations. The main risk factor for diabetic neuropathy is hyperglycemia. In the DCCT (Diabetes Control and Complications Trial, 1995) study, the annual incidence of neuropathy ...
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