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The functional group derived from adamantane is adamantyl, formally named as 1-adamantyl or 2-adamantyl depending on which site is connected to the parent molecule. Adamantyl groups are a bulky pendant group used to improve the thermal and mechanical properties of polymers. [32] [33]
APINACA (AKB48, N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide) is a drug that acts as a reasonably potent agonist for the cannabinoid receptors. [2] It is a full agonist at CB 1 with an EC 50 of 142 nM [3] and K i of 3.24 nM (compared to the K i of Δ 9-THC at 28.35 nM and JWH-018 at 9.62 nM), [4] while at CB 2 it acts as a partial agonist with an EC 50 of 141 nM [3] and K i of 1.68 nM ...
Adamantyl-THPINACA (ATHPINACA, AD-THPINACA) [1] is an indazole-based synthetic cannabinoid, [2] which was first reported to Europol in Slovenia in January 2015. [3] It is known as both the 1-adamantyl and 2-adamantyl isomers (SGT-40 and SGT-194 respectively), which can be distinguished by GC-EI-MS. [4]
Amantadine is the organic compound 1-adamantylamine or 1-aminoadamantane, which consists of an adamantane backbone with an amino group substituted at one of the four tertiary carbons. [60] Rimantadine is a closely related adamantane derivative with similar biological properties; [ 61 ] both target the M2 proton channel of influenza A virus .
APICA (2NE1, SDB-001, N-(1-adamantyl)-1-pentyl-1H-indole-3-carboxamide) is an indole based drug that acts as a potent agonist for the cannabinoid receptors. [1]It had never previously been reported in the scientific or patent literature, and was first identified by laboratories in Japan in March 2012 as an ingredient in synthetic cannabis smoking blends, along with its indazole derivative ...
Rimantadine (INN, sold under the trade name Flumadine [1]) is an orally administered antiviral drug [2] used to treat, and in rare cases prevent, influenzavirus A infection. . When taken within one to two days of developing symptoms, rimantadine can shorten the duration and moderate the severity of influ
1-Adamantanecarboxylic acid is an organic compound with the formula (CH 2) 6 (CH) 3 (CCO 2 H). A white solid, it is the simplest carboxylic acid derivative of adamantane . The compound is notable for its synthesis by carboxylation of adamantane.
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