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  2. Porphyria - Wikipedia

    en.wikipedia.org/wiki/Porphyria

    Porphyria / p ɔːr ˈ f ɪr i ə / is a group of disorders in which substances called porphyrins build up in the body, adversely affecting the skin or nervous system. [1] The types that affect the nervous system are also known as acute porphyria, as symptoms are rapid in onset and short in duration. [1]

  3. Porphyria cutanea tarda - Wikipedia

    en.wikipedia.org/wiki/Porphyria_cutanea_tarda

    Porphyria cutanea tarda is the most common subtype of porphyria. [1] The disease is named because it is a porphyria that often presents with skin manifestations later in life. The disorder results from low levels of the enzyme responsible for the fifth step in heme production. Heme is a vital molecule for all of the body's organs.

  4. Pseudoporphyria - Wikipedia

    en.wikipedia.org/wiki/Pseudoporphyria

    A personal and family history of hepatitis, porphyria, or photosensitivity disorder must be sought. Although a genetic factor has not been considered in pseudoporphyria, one case of monozygotic twins developing pseudoporphyria after excessive UV-A exposure from long-term tanning bed use has been documented.

  5. Variegate porphyria - Wikipedia

    en.wikipedia.org/wiki/Variegate_porphyria

    Variegate porphyria has an autosomal dominant pattern of inheritance. Mutations in the PPOX gene cause variegate porphyria. [4] The PPOX gene makes a membrane bound mitochondrial enzyme called protoporphyrinogen oxidase, which is critical to the chemical process that leads to heme production. The activity of this enzyme is reduced by 50 percent ...

  6. Acute intermittent porphyria - Wikipedia

    en.wikipedia.org/wiki/Acute_intermittent_porphyria

    Acute intermittent porphyria (AIP) is a rare metabolic disorder affecting the production of heme resulting from a deficiency of the enzyme porphobilinogen deaminase. It is the most common of the acute porphyrias .

  7. Silent Rage - Wikipedia

    en.wikipedia.org/wiki/Silent_Rage

    In a small Texas town, John Kirby, a mentally ill man, kills two members of the family with whom he was staying. Sheriff Daniel "Dan" Stevens and his deputy Charlie, respond and eventually arrest John, but he breaks out of the handcuffs, overpowers the other officers and grabs a shotgun, forcing the officers to shoot him.

  8. Erythropoietic porphyria - Wikipedia

    en.wikipedia.org/wiki/Erythropoietic_porphyria

    X-linked sideroblastic anemia or "X-linked dominant erythropoietic protoporphyria", associated with ALAS2 (aminolevulinic acid synthase), has also been described.X-linked dominant erythropoietic protoporphyria (XDEPP) is caused by a gain of function mutation in the ALAS2 (5-aminolevulinate synthase) gene; that gene encodes the very first enzyme in the heme biosynthetic pathway.

  9. List of Murder, She Wrote characters - Wikipedia

    en.wikipedia.org/wiki/List_of_Murder,_She_Wrote...

    In his final appearance, Pierce briefly becomes Sheriff when Amos Tupper retires but quickly loses the job when he commits and is arrested for murder. Played by John Astin , who had previously appeared in the season 1 episode "Hooray for Homicide," and later appeared in the season 11 episode "Film Flam", portraying different characters.