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Alpha-synuclein is a synuclein protein primarily found in neural tissue, making up as much as one percent of all proteins in the cytosol of brain cells. [17] It is expressed highly in neurons within the frontal cortex, hippocampus, striatum, and olfactory bulb, [17] but can also be found in the non-neuronal glial cells. [18]
Stock name Symbol Country of origin A. O. Smith Corporation: AOS: US A10 Networks, Inc. ATEN: US AAC Holdings Inc. AAC: US AAR Corporation: AIR: US Aaron's Inc.
An anti-α-synuclein drug, or an α-synuclein inhibitor, is a drug which blocks or inhibits α-synuclein. [ 1 ] [ 2 ] α-Synuclein is a protein which is thought to be involved in the development and progression of α-synucleinopathies including Parkinson's disease , dementia with Lewy bodies , and multiple system atrophy .
Companies listed on the New York Stock Exchange are in the following lists, alphabetically. Companies listed on the New York Stock Exchange (0–9) Companies listed on the New York Stock Exchange (A) Companies listed on the New York Stock Exchange (B) Companies listed on the New York Stock Exchange (C) Companies listed on the New York Stock ...
Interest in the synuclein family began when alpha-synuclein was found to be mutated in several families with autosomal dominant Parkinson's disease. [ 3 ] All synucleins have in common a highly conserved alpha-helical lipid-binding motif with similarity to the class-A2 lipid-binding domains of the exchangeable apolipoproteins .
A ticker symbol or stock symbol is an abbreviation used to uniquely identify publicly traded shares of a particular stock or security on a particular stock exchange. Ticker symbols are arrangements of symbols or characters (generally Latin letters or digits) which provide a shorthand for investors to refer to, purchase, and research securities.
The DNA repair function of alpha-synuclein appears to be compromised in Lewy body inclusion bearing neurons, and this may trigger cell death. Study of synucleinopathy mouse models of Parkinson's disease indicates that alpha-synuclein pathogenesis is associated with increased DNA damage and activation of the DNA damage response.
This is a list of companies having stocks that are included in the S&P SmallCap 600 stock market index. The index, maintained by S&P Dow Jones Indices, comprises the common stocks of 600 small-cap, mostly American, companies. Although called the S&P 600, the index contains 602 stocks because it includes two share classes of stock from 2 of its ...