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Permethrin is toxic to cats; however, it has little effect on dogs. [4] [49] [50] Many cats die after being given flea treatments intended for dogs, or by contact with dogs having recently been treated with permethrin. [51] In cats it may induce hyperexcitability, tremors, seizures, and death. [52]
Contemporary commercial products for the topical treatment of flea infestations on pets contain pesticides such as imidacloprid, permethrin, and (S)-methoprene. All flea-control products are recommended to be used at least half-yearly because the lifecycle of flea can last up to a year. [ 5 ]
The active ingredients are imidacloprid, permethrin, and pyriproxyfen. This product is toxic to cats, [ 2 ] and it is not recommended to use it on dogs which share an environment with cats. [ 1 ] The product is applied onto the skin; administration of the product into the mouth can cause adverse effects.
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Poisoning can occur if pyrethroid containing flea treatment products, which are intended for dogs, are used on cats. The livers of cats detoxify pyrethroids via glucuronidation more poorly than dogs, which is the cause of this difference. [15]