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Remdesivir and GS-441524 were both found to be effective in vitro against feline coronavirus strains responsible for feline infectious peritonitis (FIP), a lethal systemic disease affecting domestic cats. Remdesivir was never tested in cats (though some vets now offer it [1]), but GS-441524 has been found to be effective treatment for FIP.
Bova, a veterinary pharmaceuticals company based in the U.K. and Australia, began selling GS-441524, a drug compound to treat FIP, in 2021 — but the drug was not available for sale in the United ...
In naturally infected cats, a recovery rate of over 80% has been observed with GS-441524 treatment in several studies and in treatment programs in countries where the drug is legalised. [ 22 ] [ 25 ] [ 26 ] [ 27 ]
FIPV causes feline infectious peritonitis, for which treatment is generally symptomatic and palliative only. The drug GS-441524 shows promise as an antiviral treatment for FIP, but at the moment it still requires further research. [4] The drug GC376 is also being studied and developed.
In 2019, GS-441524 was shown to have promise for treating feline infectious peritonitis caused by a coronavirus. [141] It has not been evaluated or approved by the US Food and Drug Administration (FDA) for the treatment of feline coronavirus or feline infectious peritonitis but has been available since 2019, through websites and social media as ...
Obeldesivir (GS-5245, ATV006) is an isobutyric ester prodrug of GS-441524 made by Gilead Sciences that is currently in Phase III trials for the outpatient treatment of COVID-19 in high risk patients. [ 1 ] [ 2 ] The purpose of the isobutyric ester modification on obeldesivir is to improve the oral bioavailability of the parent nucleoside, GS ...