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It is the most widely used "genetic background" for genetically modified mice for use as models of human disease. They are the most widely used and best-selling mouse strain due to the availability of congenic strains, easy breeding, and robustness. [1] The median lifespan of C57BL/6 mice is 27–29 months and the maximum lifespan is about 36 ...
Unlike most laboratory mouse strains, the C57BL/6 drinks alcoholic beverages voluntarily. It is more susceptible than average to morphine addiction, atherosclerosis, and age-related hearing loss. [11] When compared directly to BALB/c mice, C57BL/6 mice also express both a robust response to social rewards [43] [44] and empathy. [45]
Rodents have been employed in biomedical experimentation from the 1650s. [1] Rodent studies up to the early 19th century were mainly physiological or toxicological.The first rodent behavioral study was carried out in 1822, a purely observational study [2], while quantitative rodent behavioral testing began in the late 19th century [1] [2].
Approximately 60% of FVB Mice regardless of sex survive to two years of age. [6] By this point, approximately 60% of surviving mice show tumors/lesions. Some sudden deaths are observed in younger animals, but most die at 15 months or older. Two years is a common life expectancy in wild-type house mice.
Charles River was founded in 1947 by Henry Foster, a young veterinarian who purchased one thousand rat cages from a Virginia farm and set up a one-person laboratory in Boston overlooking the Charles River. To fulfill the regional need for laboratory animal models, he bred, fed, and cared for the animals and personally delivered them to local ...
Similar to other rodenticides, the preparation requires 3–7 days to be effective. Rather than killing rodents through internal haemorrhaging as anticoagulants do, [9] PCC affects a rodent’s digestive system, causing acute dehydration due to its extremely absorptive nature (corn cob has been used in applications such as oil spills in water bodies, seed drying and de-icing). [10]
The genetically modified mouse in which a gene affecting hair growth has been knocked out (left) shown next to a normal lab mouse. A genetically modified mouse, genetically engineered mouse model (GEMM) [1] or transgenic mouse is a mouse (Mus musculus) that has had its genome altered through the use of genetic engineering techniques.
This black coloured mouse is a sub-strain of C57BL/6 created in 1921 by C. C. Little at the Bussey Institute for Research in Applied Biology. It is used widely in genetics, toxicology and as pet. [20] The majority of the genome is from M. m. domesticus, while smaller portion is of M. m. molossinus. [21]