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A new study found a link between SGLT-2 inhibitors and a significantly lower risk of dementia in people with diabetes. Here's what doctors say about the link.
Some researchers are investigating how metformin, a common drug used to treat diabetes, may help prolong healthspan and lifespan. What evidence is there to support this notion?
When the scientists looked at dementia subtypes, they found that SGLT-2 inhibitors were linked to 52% lower risk of vascular dementia, and 39% lower risk of Alzheimer’s disease.
A 2017 review found that people with diabetes who were taking metformin had lower all-cause mortality. [231] They also had reduced cancer and cardiovascular disease compared with those on other therapies. [231] In people without diabetes, metformin does not appear to reduce the risk of cancer and cardiovascular disease. [237]
The medication most commonly may cause stomach upset and symptoms such as diarrhea but in general is well tolerated and has a relatively low chance of causing hypoglycemia. [35] One rare (about 1% chance) but serious side affect of metformin is that it can cause lactic acidosis, usually in patients with poor kidney function. [35]
DLB is diagnosed when cognitive symptoms begin before or at the same time as parkinsonism. Parkinson's disease dementia is the diagnosis when Parkinson's disease is well established before the dementia occurs; that is, the onset of dementia is more than a year after the onset of parkinsonian symptoms. [9]
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