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Because malate dehydrogenase is closely tied to the citric acid cycle, studies have proposed and experimentally demonstrated that citrate is an allosteric regulator of malate dehydrogenase depending on the concentrations of L-malate and NAD +. This may be due to deviations observed in the kinetic behavior of malate dehydrogenase at high ...
Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the cytoplasm and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria.
Malate dehydrogenase, mitochondrial also known as malate dehydrogenase 2 is an enzyme that in humans is encoded by the MDH2 gene. [ 5 ] Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate , utilizing the NAD/NADH cofactor system in the citric acid cycle.
All of the enzymes for the citric acid cycle are in the matrix (e.g. citrate synthase, isocitrate dehydrogenase, α-ketoglutarate dehydrogenase, fumarase, and malate dehydrogenase) except for succinate dehydrogenase which is on the inner membrane and is part of protein complex II in the electron transport chain.
In enzymology, a malate dehydrogenase (oxaloacetate-decarboxylating) (EC 1.1.1.38) is an enzyme that catalyzes the chemical reaction below (S)-malate + NAD + pyruvate + CO 2 + NADH. Thus, the two substrates of this enzyme are (S)-malate and NAD +, whereas its 3 products are pyruvate, CO 2, and NADH.
In enzymology, a malate dehydrogenase (NADP +) (EC 1.1.1.82) is an enzyme that catalyzes the chemical reaction (S)-malate + NADP + ⇌ {\displaystyle \rightleftharpoons } oxaloacetate + NADPH + H + Thus, the two substrates of this enzyme are (S)-malate and NADP + , whereas its 3 products are oxaloacetate , NADPH , and H + .
Malate dehydrogenase (decarboxylating) (EC 1.1.1.39) or NAD-malic enzyme (NAD-ME) is an enzyme that catalyzes the chemical reaction (S)-malate + NAD + pyruvate + CO 2 + NADH. Thus, the two substrates of this enzyme are (S)-malate and NAD +, whereas its three products are pyruvate, CO 2, and NADH.
After malate reaches the mitochondrial matrix, it is converted by mitochondrial malate dehydrogenase into oxaloacetate, during which NAD + is reduced with two electrons to form NADH. Oxaloacetate is then transformed into aspartate (since oxaloacetate cannot be transported into the cytosol) by mitochondrial aspartate aminotransferase.