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Interneurons can be further broken down into two groups: local interneurons and relay interneurons. [4] Local interneurons have short axons and form circuits with nearby neurons to analyze small pieces of information. [5] Relay interneurons have long axons and connect circuits of neurons in one region of the brain with those in other regions. [5]
Each of these interneuron class can be further divided into diverse subpopulations of neurons with distinct neurotransmitter phenotype, axonal projection and function during locomotion. [38] For example, V2 interneurons are ipsilaterally projecting that can be further classified as excitatory V2a and inhibitory V2b.
Neurons are the excitable cells of the brain that function by communicating with other neurons and interneurons (via synapses), in neural circuits and larger brain networks. The two main neuronal classes in the cerebral cortex are excitatory projection neurons (around 70-80%) and inhibitory interneurons (around 20–30%). [2]
Projection fibers consist of efferent and afferent fibers uniting the cortex with the lower parts of the brain and with the spinal cord. In human neuroanatomy, bundles of axons (nerve fibers) called nerve tracts , within the brain, can be categorized by their function into association tracts , projection tracts , and commissural tracts .
Medium spiny neurons (MSNs), also known as spiny projection neurons (SPNs), are a special type of inhibitory GABAergic neuron representing approximately 90% of neurons within the human striatum, a basal ganglia structure. [1] Medium spiny neurons have two primary phenotypes (characteristic types): D1-type MSNs of the direct pathway and D2-type ...
In neuroscience, Golgi cells are the most abundant inhibitory interneurons found within the granular layer of the cerebellum. [1] Golgi cells can be found in the granular layer at various layers. [2] The Golgi cell is essential for controlling the activity of the granular layer. [3] They were first identified as inhibitory in 1964. [4]
A multipolar neuron is a type of neuron that possesses a single axon and many dendrites (and dendritic branches), allowing for the integration of a great deal of information from other neurons. These processes are projections from the neuron cell body. Multipolar neurons constitute the majority of neurons in the central nervous system.
The interneurons of the stratum lucidum are generally found to be local circuit neurons remaining within the CA3 region. A majority of the interneuron axons remain within the stratum lucidum but some also extend to the stratum radiatum and stratum lacunosum-molecular above the radiatum as well as to the CA1 and hilur regions. [1]