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Hemosiderin hyperpigmentation is pigmentation due to deposits of hemosiderin, and occurs in purpura, haemochromatosis, hemorrhagic diseases, and stasis dermatitis. [ 1 ] : 853 See also
Hemosiderin or haemosiderin is an iron-storage complex that is composed of partially digested ferritin and lysosomes. The breakdown of heme gives rise to biliverdin and iron. [1] [2] The body then traps the released iron and stores it as hemosiderin in tissues. [3] Hemosiderin is also generated from the abnormal metabolic pathway of ferritin. [3]
Hemosiderin depositionon on the surface of the brain and spinal cord due to chronic bleeding in the subarachnoid space is known as superficial siderosis. Hemosiderin collects in the skin and is slowly removed after bruising; hemosiderin may remain in some conditions such as stasis dermatitis.
The stain is an important histochemical stain used to demonstrate the distribution and amount of iron deposits in liver tissue, often in the form of a biopsy. [6] [7] Perls's procedure may be used to identify excess iron deposits such as hemosiderin deposits (hemosiderosis) and in conditions such as hereditary hemochromatosis. [8]
Histopathology of the liver, showing Kupffer cells with significant hemosiderin deposition (shown next to a hepatocyte with lipofuscin pigment, which is a common normal finding). H&E stain. Prussian blue iron staining, highlighting the hemosiderin pigment as blue. This finding indicates mesenchymal iron overload (within Kupffer cells and/or ...
Micrograph of the spleen showing darkly stained, spheroid Gamna-Gandy bodies (arrows) outside the vessel wall at the center. Also shown is diffusely scattered, brown, granular hemosiderin pigment (arrowheads), indicating previous hemorrhage (hematoxylin & eosin staining, 40x magnification).
26 Pictures Of Skin Rashes Atopic Dermatitis. Atopic dermatitis is a dry, red, weepy, crusty rash that appears patchy and oval shaped, says Dr. Parikh. The rash is extremely itchy and can turn ...
Doucas and Kapetanakis pigmented purpura, also known as eczematoid purpura, [1] or eczematoid-like purpura, [2] is a skin condition characterized by scaly and eczematous patches, which also have petechiae and hemosiderin staining. [3]: 830 It is a lymphocytic capillaritis of unknown cause. Lesions consist of erythematous and purpuric macules ...