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Yao syndrome (YAOS), formerly called NOD2-associated autoinflammatory disease, [1] is an autoinflammatory syndrome involving episodes of fever and abnormal inflammation affecting many parts of the body, particularly the skin, joints, and gastrointestinal system.
It is also important to rule out systemic diseases that can cause hives, such as vasculitis (urticarial vasculitis), Schnitzler's syndrome, Gleich's syndrome, or thyroid disease. [32] The specific symptoms, triggers, and results of skin and blood tests can help differentiate autoimmune urticaria from these other conditions.
Autoinflammatory diseases (AIDs) are a group of rare disorders caused by dysfunction of the innate immune system. These responses are characterized by periodic or chronic systemic inflammation , usually without the involvement of adaptive immunity.
Skin Biology and Diseases. The programs comprising Skin Biology and Diseases support a broad portfolio of basic, translational, and clinical research in skin. These efforts include work on the developmental and molecular biology of skin and skin appendages (such as the hair follicle), the study of skin as an immune organ, and the genetics of ...
A key difference is a malfunction of the innate immune system in autoinflammatory diseases, whereas in autoimmune diseases there is a malfunction of the adaptive immune system. [8] Symptoms of autoimmune diseases can significantly vary, primarily based on the specific type of the disease and the body part that it affects.
Pyoderma gangrenosum is a rare, inflammatory skin disease where painful pustules or nodules become ulcers that progressively grow. [3] Pyoderma gangrenosum is not infectious. [3] Treatments may include corticosteroids, ciclosporin, infliximab, or canakinumab. [2] The disease was identified in 1930.
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