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A swaying granulator or a roll compactor can be used for the dry granulation. Dry granulation can be conducted under two processes; either a large tablet (slug) is produced in a heavy duty tabletting press or the powder is squeezed between two counter-rotating rollers to produce a continuous sheet or ribbon of material.
Tablet formulations are designed and tested using a laboratory machine called a Tablet Compaction Simulator or Powder Compaction Simulator. This is a computer controlled device that can measure the punch positions, punch pressures, friction forces, die wall pressures, and sometimes the tablet internal temperature during the compaction event.
The plate compactor, vibrating plate, or tamper, has a large vibrating baseplate and is suited for creating a level grade, while the rammer compactor has a smaller foot. The rammer, or trench rammer, is mainly used to compact the backfill in narrow trenches for water or gas supply pipes etc. Road rollers may also have vibrating rollers.
Pharmaceutical manufacturing is the process of industrial-scale synthesis of pharmaceutical drugs as part of the pharmaceutical industry. The process of drug manufacturing can be broken down into a series of unit operations , such as milling , granulation , coating , tablet pressing , and others.
A tablet press in operation An old rotary tablet press. A tablet press is a mechanical device that compresses powder into tablets of uniform size and weight. A tablet press can be used to manufacture tablets of a wide variety of materials, including pharmaceuticals, nutraceuticals, cleaning products, industrial pellets and cosmetics.
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Compaction simulation is the modelling of granular matter when compressed into a dense state that is achieved through the reduction of the air void. The term is also commonly used to mean compaction using a compaction simulator. This is a high performance programmable servo-controlled press for simulating production presses, typically in the ...
The pill rollers : A book on apothecary antiques and drug store collectibles / by Charles G. and Lillian C. Richardson. Harrisonburg, Va.: Old Fort Press; 2003. Show Globes. University of Arizona College of Pharmacy Museum, 2010. Hammond CV. An international pharmaceutical symbol. J Am Pharm Assoc. 1972 Dec;NS12:615,620, 632.