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  2. Rofecoxib - Wikipedia

    en.wikipedia.org/wiki/Rofecoxib

    The therapeutic recommended dosages were 12.5, 25, and 50 mg with an approximate bioavailability of 93%. [12] [13] [14] Rofecoxib crossed the placenta and blood–brain barrier, [12] [13] [15] and took 1–3 hours to reach peak plasma concentration with an effective half-life (based on steady-state levels) around 17 hours.

  3. Cyclooxygenase-2 inhibitor - Wikipedia

    en.wikipedia.org/wiki/Cyclooxygenase-2_inhibitor

    The VIGOR (Vioxx Gastrointestinal Outcomes Research) trial, "which was the making of Merck's drug rofecoxib (Vioxx)," [46] was at the center of a dispute about the ethics of medical journals. In the VIGOR trial, over 8,000 patients were randomized to receive either naproxen or rofecoxib (Vioxx).

  4. On (company) - Wikipedia

    en.wikipedia.org/wiki/On_(company)

    On Holding AG is an athletic shoe and performance sportswear company originating in Switzerland that designs and markets sports clothing and running shoes.. In 2019, the company held 40% of the running shoe market in Switzerland and 10% in Germany. [2]

  5. Discovery and development of cyclooxygenase 2 inhibitors

    en.wikipedia.org/wiki/Discovery_and_development...

    [5] [6] It took less than eight years to develop and market the first COX-2 inhibitor, with Celebrex launched in December 1998 and Vioxx launched in May 1999. [ 7 ] [ 8 ] Celecoxib and other COX-2 selective inhibitors, valdecoxib , parecoxib , and mavacoxib , were discovered by a team at the Searle division of Monsanto led by John Talley .

  6. Helen Mirren’s go-to sneakers are comfortable straight out of ...

    www.aol.com/lifestyle/helen-mirrens-go-to...

    The rest of the shoe is environmentally friendly too. The vegan insole is made with a blend of cork, bio memory foam and organic mamona oil, while the lining, laces, threads and labels are made ...

  7. Vioxx - Wikipedia

    en.wikipedia.org/?title=Vioxx&redirect=no

    From or to a drug trade name: This is a redirect from (or to) the trade name of a drug to (or from) the international nonproprietary name (INN).

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