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Topical 5-fluorouracil (5-FU, Efudex, Carac) has been shown to be an effective therapy for diffuse, but minor actinic cheilitis. 5-fluorouracil works by blocking DNA synthesis. Cells that are rapidly growing need more DNA, so they accumulate more 5-fluorouracil, resulting in their death. Normal skin is much less affected.
Fluorouracil has been given systemically for anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers (especially head and neck cancers). [12] It has also been given topically (on the skin) for actinic keratoses, skin cancers and Bowen's disease [12] (a type of cutaneous squamous-cell carcinoma), and as eye drops for treatment of ocular surface squamous neoplasia. [13]
Skin flora, also called skin microbiota, refers to microbiota (communities of microorganisms) that reside on the skin, typically human skin. Many of them are bacteria of which there are around 1,000 species upon human skin from nineteen phyla. [1] [2] Most are found in the superficial layers of the epidermis and the upper parts of hair follicles.
To manage eczema in these areas, protect your skin from extreme cold or high heat and avoid rapid temperature changes, like going from a warm fire indoors into a freezing cold car. Polar Climate
You may have been warned about this before, and perhaps have even seen the results of stress on your skin when you have a big presentation at work, or durin The truth about stress: How it affects ...
The skin weighs an average of four kilograms, covers an area of two square metres, and is made of three distinct layers: the epidermis, dermis, and subcutaneous tissue. [1] The two main types of human skin are: glabrous skin, the hairless skin on the palms and soles (also referred to as the "palmoplantar" surfaces), and hair-bearing skin. [3]
Skin cancer has been on the rise in the U.S. for years, with 1 in 5 people developing the disease by age 70, according to the Skin Cancer Foundation. But there’s an easy and powerful tool that ...
Topical creams, such as 5-fluorouracil or imiquimod, may require daily application to affected skin areas over a typical time course of weeks. [ 13 ] Cryotherapy is frequently used for few and well-defined lesions, [ 14 ] but undesired skin lightening, or hypopigmentation, may occur at the treatment site. [ 15 ]