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Mechanistic bases for adverse vaccine reactions and vaccine failures. Adv Vet Med. 1999;41:681-700. doi: 10.1016/s0065-3519(99)80053-6. PMID: 9890054; PMCID: PMC7149317.
The DA2PPC vaccine protects against the debilitating and deadly disease canine distemper. This disease is a fatal viral illness that causes neurologic dysfunction, pneumonia, nonspecific systemic symptoms such as fever and fatigue, and weight loss, as well as upper respiratory symptoms and diarrhea, poor appetite, and vomiting. [4]
Adverse effects of vaccinations are mild, but the most common effect observed up to 30 days after administration is nasal discharge. [8] Vaccinations are not always effective. In one study it was found that 43.3% of all dogs in the study population with respiratory disease had in fact been vaccinated.
According to the U.S. Centers for Disease Control and Prevention, while "any vaccine can cause side effects", [11] most side effects are minor, primarily including sore arms or a mild fever. [11] Unlike most medical interventions vaccines are given to healthy people, where the risk of side effects is not as easily outweighed by the benefit of ...
Approximately half of the pet owners surveyed expressed some degree of vaccine hesitancy — with 53% saying they believed vaccines administered to dogs were unsafe, ineffective or unnecessary ...
Dog vaccination against rabies. Vaccination of dogs is the practice of animal vaccination applied to dogs. Programs in this field have contributed both to the health of dogs and to the public health. In countries where routine rabies vaccination of dogs is practiced, for example, rabies in humans is reduced to a very rare event.
Assessments of reactogenicity are carried out to evaluate the safety and usability of an experimental vaccine (see Investigational New Drug). It is unclear whether a higher degree of reactogenicity to a vaccine correlates with more severe adverse events, which would require hospitalization or are life-threatening. Adverse events have been ...
Type A: augmented pharmacological effects, which are dose-dependent and predictable [5]; Type A reactions, which constitute approximately 80% of adverse drug reactions, are usually a consequence of the drug's primary pharmacological effect (e.g., bleeding when using the anticoagulant warfarin) or a low therapeutic index of the drug (e.g., nausea from digoxin), and they are therefore predictable.