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A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
8654 242202 Ensembl ENSG00000138735 ENSMUSG00000053965 UniProt O76074 Q8CG03 RefSeq (mRNA) NM_033437 NM_001083 NM_033430 NM_153422 RefSeq (protein) NP_001074 NP_236914 NP_246273 NP_700471 Location (UCSC) Chr 4: 119.49 – 119.63 Mb Chr 3: 122.52 – 122.65 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cyclic guanosine monophosphate-specific phosphodiesterase type 5 is an enzyme (EC ...
The PDE5 inhibitors sildenafil, vardenafil and tadalafil are competitive and reversible inhibitors of cGMP hydrolysis by the catalytic side of PDE5. The structures of vardenafil and sildenafil are similar, they both contain similar structured purine ring of cGMP that contributes their features to act as a competitive inhibitor of PDE5.
PDE5 inhibitors increase blood flow to your privates, ... (BPH), a common prostate condition among aging men that can lead to enlarged prostate and urinary symptoms ...
Other PDE5 inhibitors, such as sildenafil (Viagra), vardenafil (Levitra), and avanafil (Stendra), will interact with Cialis. ... An enlarged prostate is common in older men and typically carries ...
A transrectal ultrasound shows the prostate has a volume of 30 to 150 cubic centimeters (cc). ... PDE5 inhibitors, such as vardenafil (Levitra) finasteride (Proscar, Propecia)