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Amlodipine has been studied in healthy volunteers following oral administration of 14 C-labelled drug. [53] Amlodipine is well absorbed by the oral route with a mean oral bioavailability around 60%; the half-life of amlodipine is about 30 h to 50 h, and steady-state plasma concentrations are achieved after 7 to 8 days of daily dosing. [7]
Levamlodipine , also known as levoamlodipine or S-amlodipine is a pharmacologically active enantiomer of amlodipine. [1] Amlodipine belongs to the dihydropyridine group of calcium channel blocker used as an antihypertensive and antianginal agent. [2] It was approved by the U.S. FDA in December 2019 and is currently marketed under the brand name ...
Each country or region has their own regulatory body. In the European Union, the European Medicines Agency has jurisdiction and the relevant documents are called the "summary of product characteristics" (SPC or SmPC) and the document for end-users is called the "patient information leaflet" or "package leaflet".
The drug combination aliskiren/amlodipine (INNs, trade names Tekamlo and Rasilamlo) is an antihypertensive. Clinical trials have shown it to be more effective than amlodipine on its own, [ 1 ] with a high dosing regime (aliskiren 300 mg/amlodipine 10 mg) being more effective than olmesartan/amlodipine with comparable tolerability.
Amlodipine/olmesartan, sold under the brand name Azor, among others is a fixed-dose combination medication used to treat high blood pressure. [5] It contains amlodipine , as the besilate, a dihydropyridine calcium channel blocker , and olmesartan medoxomil , an angiotensin II receptor blocker .
Dihydropyridine calcium channel blockers can worsen proteinuria in patients with nephropathy. [9] This CCB class is easily identified by the suffix "-dipine". Amlodipine (Norvasc) Aranidipine (Sapresta) Azelnidipine (Calblock) Barnidipine (HypoCa) Benidipine (Coniel) Cilnidipine (Atelec, Cinalong, Siscard) Not available in US; Clevidipine ...
Amlodipine/benazepril, sold under the brand name Lotrel among others, is a fixed-dose combination medication used to treat high blood pressure. [1] It is a combination of amlodipine, as the besilate, a calcium channel blocker, and benazepril, an angiotensin converting enzyme inhibitor. [1] It may be used if a single agent is not sufficient. [1]
It contains olmesartan medoxomil, an angiotensin II receptor blocker, amlodipine, as the besilate, a calcium channel blocker, and hydrochlorothiazide, a thiazide diuretic. [3] It is taken by mouth . [ 3 ]